Fructose and inflammation

Fructose increases inflammatory processes. One is called "intercellular adhesion molecule-1" or ICAM-1. Another is monocyte chemotactic protein 1, or MCP-1. [link]. ICAM-1 is associated with the body's response to pain [link], but also with kidney failure and senile plaques [link]. It can slow down the brain's ability to repair itself by mediating (increasing) dymelination [link]. MCP-1 is associated with inflammation in the kidneys. [link]

This is just a copy paste of things that inhibit or reduce those inflammatory processes. Olive oil and tea can be found in both lists. 




ICAM-1.

 Natural licorice (link)
Lycopene (Tomatoes #1, Watermelons, soups, grapefruit, baked beans, sweet red pepper, parsley, basil) (link)
Olive oil [link]
EGCG (found in tea) [link] via increased insulin [link]


MCP-1.

Olive oil and quercetin inhibit MCP-1. [link]

Quercetin can be found in fresh onions, cranberries, green chili peppers, red leaf lettuce, kale, asparagus, spinach, sweet peppers [link]

EGCG (found in tea) reduces expression of MCP-1 [link].


Black raspberries inhibit α–Glucosidase[link], which decreases MCP-1 levels [link].

Red raspberries, peaches, and purple corn [link] contain cyanidin 3-glucoside, which reduces levels of MCP-1 and attenuates obesity-associated insulin resistance. [link]

Who are methane's foes?

I'm not a climatologist I should say that first off. I'm just a scared and concerned citizen.

Before you continue reading remember to please please please call your governor and state representatives and tell them you want action on global warming, especially that you want to see more investments in energy efficient buildings, especially factories, and also renewable energy like solar and especially wind.

Anyway, I'm scared about methane and carbon emissions at the Arctic at the moment and I want to give myself some hope, so I'm just giving myself some homework about it. 

What are some ways to disrupt methane from messing up this planet?

1. By feeding garlic and seaweed to cattle:

California scientists hope feeding cows seaweed will make them less gassy — which could be great news for the environment

• Researchers in California are testing whether seaweed in cow diets can reduce climate pollutants.
• The state's livestock sector — mostly the dairy sector — is responsible for an estimated 55 percent of methane emissions in the state.
• Methane is created in cattle production when cows burp, pass gas and poop.
• Preliminary findings show a touch of seaweed added to the cattle's diet may reduce cow gassiness by "well over 30 percent."

2. With methane-eating microorganisms in freshwater wetlands: 

The study results are published this week in the journal Nature Communications by biologist Samantha Joye of the University of Georgia and colleagues.
The researchers report that high rates of anaerobic (no oxygen) methane oxidation in freshwater wetlands substantially reduce atmospheric emissions of methane.

3. "by positively charging gold nanoparticles"

While methane adsorption depends on the gold charge, oxygen adsorption does not, so tuning the gold charge provides a way for researchers to independently tune the methane absorption. By making the methane adsorb approximately three orders of magnitude more strongly than the oxygen, the researchers could perform delicate methane oxidation on gold at low temperatures and pressures, which is a requirement for many environmental and economic applications such as producing useful chemicals.

Read more at: https://phys.org/news/2013-09-delicate-oxidation-greenhouse-gas-chemicals.html#jCp

While methane adsorption depends on the gold charge, oxygen adsorption does not, so tuning the gold charge provides a way for researchers to independently tune the methane absorption. By making the methane adsorb approximately three orders of magnitude more strongly than the oxygen, the researchers could perform delicate methane oxidation on gold at low temperatures and pressures, which is a requirement for many environmental and economic applications such as producing useful chemicals.

What does my trauma feel like?

Today I was thinking about what it means to be on welfare and to be an abuse survivor. I know for a fact lack of healthcare hurt my life alongside the abuse but I find it really difficult to pin down exactly why. It almost feels like bad luck sometimes, and I have no meaning to assign to my pain.

Do you want to know why? I went through most of my schooling without glasses and it feels like someone stole my life from me.

In first grade they thought I was squinting at the board and asked me if I wanted glasses and I said no, because I didn't "need them." Really, I was afraid I'd look goofy in them.

I don't even know who to blame. I can hardly blame myself at 7 years old for the cultural stigma. I can't blame my parents. It didn't seem like a problem because my eyes were good enough to read books all the way through, but I had to take breaks every 3 pages and almost fell asleep exhausted halfway through Harry Potter. My eyes were healthy enough they could pass vision tests somehow, until a newer machine in high school barely picked up on it. I suppose society is to blame but where is the fun in hating something so vague?

I faked my way through literature and history in middle school, which were the most reading-intensive. As my class matured, the workload increased, and I spent a lot of time after that complaining of getting tired from doing schoolwork, which everyone agreed was fair but not a good enough reason to avoid work altogether. After having all but failed 8th grade, I was eventually dropped to lower and lower classes. But it always just seemed like a little more encouragement should do the trick.

I suppose internalizing this lie and having to pass it onto my teachers provided me good insight into how people lie. For example, you promise everybody you'll do exactly what they want, and then pick just one person to actually follow through on. That way you satisfy one person at least, and stay in the good graces of the rest for at least making an attempt. What's ugly is once they're done giving you second chances, you either get one last exception or you face the music and must produce a sincere sounding apology. It was awful having to do this to my teachers who loved me unconditionally, but it was the only way I knew how to avoid seeming like I was just trying to be a bad student on purpose.

Making matters worse, my father started facing serious mental illness throughout my childhood, and by high school it was spiraling out of control.  He lost all of his empathy, drowned himself in beer, and my mom was resigned to him degenerating into nothing. He decided I "had to go to school" and it was now his solemn duty to force me to religious services and school by threats of taking away my possessions, my bedroom door, and marching me there with an arm twisted behind my back. He could only punish me so much, and I eventually won. Going to school was almost an escape from it, but not enough. I trudged through as best I could and once Junior year hit I decided to stop going entirely out of protest to everything.

You don't come away unchanged from all that.  I have a sour grapes attitude toward everything. After years of being told you're capable and failing at doing anything, you stop believing good things can happen. I still have a habit of placating and charming people, but I have a lot less interest in whether they care. I have some patience but it really takes effort to summon up compassion. I can't imagine going to services even though they are less than a block away these days. It's a shame because I had gotten a lot out of them for a time being. I liked the singing a lot. I am unusually extroverted as well and miss the chit-chat.

I do have some rare, lucky moments of mercy. For example, when I decided it wasn't fair what happened to me or my dad. I researched both of our conditions as best I could and took appropriate steps to get him help. Knowing exercise would be foundational for his addiction rehab and overall mental health, I ordered an exercise bike that I put next to the TV. I told him it was mine but he could use it and he soon made it a daily routine. The story of his medication is interesting. He resisted the diagnosis that suits his condition in favor of a much more mild one. Oddly, this benefitted him even more, because the medication for his condition is almost non-existant, while the one that is prescribed for his self-diagnosed condition is helping him a lot. He was able to settle into a medicine and exercise routine and on a good day seems almost like his old self again.

The irony is I'm still suffering at home in failure and he's got his life together. He's running two support groups now, taking a class, cooking dinner and following the news on the radio. I'm chipping away at sleep problems, an eating disorder, mood disorder, and I can't hear a word of praise without immediately discounting it. I'll never forget the cruelty involved in trying to accustom me into being an upstanding member of society, and the emptiness inside that I feel when I try to remember something nice from those days. I won't forget the lie about how my success is just around the corner. I can't even complete an English class now without having panic attacks. I feel like my life was stolen from me. If I weren't so opposed to the idea basically on the grounds of upsetting my family this could be a suicide note.

I said I don't know who to blame but someone sure cheaped out on the eye tests, right? Who failed to do any creative research about my father's condition? It has to be better organized. Maybe doctors overbook, maybe they only know about treatments covered in the media. Maybe the frenzy of new treatments encourages them to balk at older generics. While people get unfairly priced out of treatments, the American medical system is so corrupt that there is a culture of just writing people off as hopeless, and I wish that criticism were aired more frequently, because right now it is hurting a lot of people like me but doesn't have a name or a face. It is just sort of the overall system doing this.

I'm getting help but all the while I'm forced to watch the system fail others. I don't mean to be more radical than thou to advocates of reform, I just want people to see the system we have now is much more rotten than people might know, and hope my story resonates and helps focus the reform effort on what really benefits people. I hope anyone basically literate in these issues can try to articulate a comprehensive criticism that helps the reform movement.

CNTNAP2 review (Schizophrenia/Autism)

Relevant studies 

Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities and core autism-related deficits" (link)

Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia" (link)

Glycine transporter I inhibitor, N-Methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia (https://www.infona.pl/resource/bwmeta1.element.elsevier-ad6cad94-4db2-3c7c-a082-d18ae6f506ae)

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development (http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.473.2553&rep=rep1&type=pdf)

GABAB-mediated rescue of altered excitatory– inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction (https://www.nature.com/articles/tp201269.pdf)

Meds 

• D-sarcosine, glycine reduces negative schizophrenia symptoms (https://www.infona.pl/resource/bwmeta1.element.elsevier-ad6cad94-4db2-3c7c-a082-d18ae6f506ae) op cit (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015107)
• clozapine* reduces social behavior deficit. The ampakines are a new class of promising compounds … It is believed that thesec ompounds may induce less excitotoxicity than drugs that are direct agonists at he NMDA receptor (http://www.schres-journal.com/article/S0920-9964(01)00311-5/abstract)(https://journals.lww.com/neuroreport/Fulltext/2001/01220/Clozapine,_but_not_haloperidol,_reverses_social.10.aspx) 
• Risperdol reduces repetitive behaviors (https://www.sciencedirect.com/science/article/pii/S0092867411010105)
• baclofen reduces behavioral deficits, symptoms of autism through GABAB rescue of excitatory–inhibitory balance (https://www.nature.com/articles/tp201269)

Diet:

• Tomatoes, coriander, beetroot (stains kitchenware) for kidneys (https://www.ncbi.nlm.nih.gov/pubmed/25602702)(http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.401.8966)(https://www.infona.pl/resource/bwmeta1.element.elsevier-653ab9b9-86f9-3f1c-ab8f-9701332944f2)
• Fisetin from strawberries prevent neurological disorders  (https://link.springer.com/article/10.1007/s12035-016-9795-4)
• Omega 3 reduces learning deficits (https://www.liebertpub.com/doi/abs/10.1089/neu.2004.21.1457)
• Zinc increases BDNF in a protective way and is deficient in kidney impairment (https://www.nature.com/articles/cddis201073) (http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12239/full)
• Curcumin/turmeric preserves plasticity although also stains kitchenware (https://www.sciencedirect.com/science/article/pii/S0014488605003274)
• Thyme via linalool to reduces aggression, compare to clozapine (https://www.sciencedirect.com/science/article/pii/S0944711309002578)
• Passionflower for GABAB effects (http://onlinelibrary.wiley.com/doi/10.1002/ptr.3352/full)