Tuesday, August 9, 2016

Prader Willi Review


Calcium, sea buckthorn, periwinkle, choline, vitamin D, vitamin K, agave, ascorbic acid, sertogenics

Opposite effect or gene


Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D3, and vitamin K1 produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome

Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and...

Angelman and Prader‐Willi syndrome: A magnetic resonance imaging study of differences in...

Small gray matter volume in orbitofrontal cortex in Prader-Willi syndrome: A voxel-based MRI study

Sea buckthorn

PDE1 and Vinpocetine
Cheung (1970), Kakiuchi and Yamazaki (1970)
simultaneously discovered PDE1 from bovine and rat
brains, respectively, a calciprotein constituted of 148
aa, as a thermostable factor named calcium-
dependent activator or regulator (CDA or CDR) or
phosphodiesterase activating factor (PAF), which
binds 4 Ca 2+ mol/mol. This protein, named
calmodulin (CaM), was shown to activate cyclic
nucleotide phosphodiesterase in a calcium-dependent
manner. This discovery allowed characterizing the
first eluted fraction of PDE activity (Peak 1 or PDE I)
isolated by chromatography from vascular smooth
muscle. Since this PDE I fraction was specifically
activated by Ca2+/CaM, it was also named CaM-
PDE1 family having three subtypes: PDE1A, PDE1B
and PDE1C and these PDE are stimulated by the
Ca 2+ -CAM. These enzymes catalyze the hydrolysis of
the cAMP and cGMP and were detected in: blood
vessels, heart, lung, testes, platelets and lymphocytes.
Vinpocetine is a PDE1 inhibitor which inhibit
Ca +2 /calmodulin-dependent phosphodiesterase (PDE)
type 1. Beside this, like vitamin E, vinpocetine is an
effective scavenger of hydroxyl radicals and shown
to inhibit lipid peroxidation in synaptosomes of
murine brain tissue and to protect against global
anoxia and hypoxia in animals.
Vinpocetine has been shown to protect neurons from
the toxicity of glutamate and Nmethyl-d-aspartate
(NMDA), lowers blood viscosity in patients with
cerebrovascular disease, has significant vasodilating
properties, decreases platelet aggregation, and
increasesand maintains erythrocyte flexibility
underoxidative stress[12].Vinpocetine iseffective in
ameliorating i.c.v. streptozotocin induced behavioural
alterations,cholinergic dysfunction and oxidative–
nitritive stress. Theobserved beneficial effects of
vinpocetine in spatialmemory processingmay be due
to its ability to restore cholinergic functions, prevent
neuronaldamage and possibly through its antioxidant
mechanism [13].

Effects of hormone replacement therapy and aging on cognition: evidence for executive dysfunction

DJ Wegesin, Y Stern - Aging, Neuropsychology, and Cognition, 2007 - Taylor & Francis
... Ovarian hormones differentially influence immunoreactivity for dopamine b-hydroxylase, choline acetyltransferase, and serotonin in the dorsolateral prefrontal cortex of adult rhesus monkeys. Journal of Comparative Neurology, 409: 438–451. View all references). ..

, vitamin D 3, and vitamin K 1 produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

JJ Lamb, MF Holick, RH Lerman, VR Konda… - Nutrition Research, 2011 - Elsevier
... any prescription or nonprescription anti-inflammatory drugs; recent use of the study botanicals; allergy to ... A second analysis, limited to participants who met the metabolic syndrome criteria at visit ... analysis, subjects were stratified by the tertile rank of baseline IGF-I concentrations. ...


Neurofilament-2H3 (NF)
1:2000 Monoclonal (mouse IgG) Dev. Studies Hybridoma Bank, Iowa 20
Neurofilament 150 kd
1:2000 Polyclonal (rabbit)
Chemicon, Temecula, CA
21, 22
Growth-associated protein 43 (GAP43)
1:2000 Monoclonal (mouse IgG) Sigma, St. Louis, MO
Vimentin 40E-C (VIM)
1:200 Monoclonal (mouse IgM) Dev. Studies Hybridoma Bank
Transiently expressed axonal glycoprotein
clone 4D7 (TAG1)
1:200 Monoclonal (mouse IgM) Dev. Studies Hybridoma Bank
20, 25
Substance P receptor (NK1R)
1:1000 Polyclonal (rabbit)
Advanced Targeting Systems,
San Diego, CA
26, 27
Cell adhesion molecule L1 (L1)
1:200 Monoclonal (rat)
Choline acetyl transferase (ChAT)
1:300 Polyclonal (goat)
Substance P (SubP)
1:500 Monoclonal (rat)
Serotonin (5HT)
1:1000 Goat
Somatostatin (SST)
1:1000 Polyclonal (rabbit)
Immunostar, Hudson, WI
Tyrosine hydroxylase (TH)
1:2000 Polyclonal (rabbit)

Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia

JS Chambers, D Thomas, L Saland, RL Neve… - Progress in Neuro- …, 2005 - Elsevier
Growth-associated protein 43 (GAP-43) expression is critical for the proper establishment of neural circuitry, a process thought to be disrupted in schizophrenia. Previous work from our laboratory demonstrated decreased GAP-43 levels in post-mortem tissue from the entire ...
Cited by 44 Related articles More

Growth-associated protein-43 (GAP-43) facilitates peptide hormone secretion in mouse anterior pituitary AtT-20 cells

C Gamby, MC Waage, RG Allen, L Baizer - Journal of Biological Chemistry, 1996 - ASBMB
Abstract The neuronal growth-associated protein (GAP)-43 (neuromodulin, B-50, F1), which is concentrated in the growth cones of elongating axons during neuronal development and in nerve terminals in restricted regions of the adult nervous system, has been implicated in

A GABAergic projection from the zona incerta to cortex promotes cortical neuron development

J Chen, AR Kriegstein - Science, 2015 - science.sciencemag.org
... 2 Synaptic responses in developing human cortical neurons from layer 1 GABAergic axons. (A to C) Neurofilament-2H3 (NF-2H3) (A) and vGat (B ... (E and F) Morphology of P7 layer ... 3, E to H). We also observed reduced spine numbers in apical dendrites after TeLC treatment (Fig. ...

Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract

N Singh, CM Trivedi, MM Lu, SE Mullican… - Circulation …, 2011 - Am Heart Assoc
... A, Immunohistochemistry for GFP and neurofilament (2H3), a marker of differentiated neurons, in frontal sections of the dorsal neural tube (DNT) and dorsal root ... of control cells stain positive for SMA (C and E), whereas mutant cells are rarely SMA-positive (D and F). G, Each GFP ...

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

EJ Williams, J Furness, FS Walsh, P Doherty - Neuron, 1994 - Elsevier
... In addition, a soluble L1-Fc chimera is shown to stimulate an increase in phosphotyrosine on the same set of neuronal ... Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Proc. ... J. Cell Biol., 113 (1991), pp. ...

Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp.

JE Urias-Silvas, PD Cani, E Delmée… - British Journal of …, 2008 - Cambridge Univ Press
... NM, Cani PD, Daubioul C & Neyrinck AM (2005) Impact of inulin and oligofructose on gastrointestinal peptides. ... Williams CM, Roberfroid MB, Thissen JP & Delzenne NM (1998) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin ...

Molecular characterisation of Ltchi7, a gene encoding a Class III endochitinase induced by drought stress in Lotus spp

G Tapia, L Morales‐Quintana, L Inostroza… - Plant …, 2011 - Wiley Online Library
... 2010 German Botanical Society and The Royal Botanical Society of ... of nodules is tightly regulated by several factors, such as environmental (nitrate, drought, cold) and endogenous hormones (Streeter 1988 ... The amino acid sequence in bold match the deduced signal peptide. ...

Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors

MK DeHamer, JL Guevara, K Hannon, BB Olwin… - Neuron, 1994 - Elsevier
... Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors. Curr. Opin. ... Birren et al., 1993; SJ Birren, L. Lo, DJ Anderson; Sympathetic neuroblasts undergo a developmental switch in trophic factor dependence. ...
Cited by 177 Related articles More

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci …

J Engele, MC Bohn - The Journal of neuroscience, 1991 - Soc Neuroscience
... is increasing evidence that other known growth factors, such as fibroblast growth factor (FGF), affect ... to the stimulation of glial pro- liferation or whether the growth factors induce synthesis ... further be excluded that these neurotrophic ac- tivities derive from fibroblasts or microglia ...

[HTML] Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors

J Yan, L Studer, RDG McKay - Journal of neurochemistry, 2001 - Wiley Online Library
Abstract CNS precursors derived from E12 rat mesencephalon proliferate in the presence of basic fibroblast growth factor and differentiate in vitro into functional dopaminergic neurons, which upon transplantation alleviate behavioral symptoms in a rat model of Parkinson's ...

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